![]() ![]() Given alone, escitalopram, but not citalopram or R- citalopram, markedly enhanced both cortical dopamine output and NMDA receptor-mediated transmission. Only escitalopram (5 mg/kg), but not citalopram (10 mg/kg), or R- citalopram (10 mg/kg), dramatically enhanced the antipsychotic-like effect of a low dose of risperidone (0.25 mg/kg), without increasing catalepsy. We examined antipsychotic efficacy using the conditioned avoidance response (CAR) test, extrapyramidal side effect (EPS) liability using a catalepsy test, dopamine outflow in the medial prefrontal cortex (mPFC) and nucleus accumbens using in vivo microdialysis in freely moving animals, and NMDA receptor-mediated transmission in the mPFC using intracellular electrophysiological recording in vitro. ![]() ![]() Here, we studied, in rats, the behavioral and neurobiological effects of adding escitalopram, citalopram, or R- citalopram to the second-generation antipsychotic drug risperidone. We have recently shown that escitalopram, but not citalopram or R- citalopram, increases firing rate and burst firing of midbrain dopamine neurons, potentiates cortical N-methyl-D-aspartate (NMDA) receptor-mediated transmission and enhances cognition, effects that might influence the outcome of concomitant antipsychotic medication. Marcus, Monica M Jardemark, Kent Malmerfelt, Anna Gertow, Jens Konradsson-Geuken, Asa Svensson, Torgny HĪntidepressant drugs are frequently used to treat affective symptoms in schizophrenia. Augmentation by escitalopram, but not citalopram or R- citalopram, of the effects of low-dose risperidone: behavioral, biochemical, and electrophysiological evidence. ![]()
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